Abstract:

Childhood-onset systemic lupus erythematosus (cSLE) is an autoimmune disease characterized by multiple organ involvement, a large number of autoantibodies and low complement. The affected organs are prone to irreversible damage, which threatens the lives of children. This article introduces the clinical characteristics of cSLE, severe lupus and monogenic lupus, and summarizes the diagnosis methods, disease activity assessment, treat-to-target, treatment principles and treatment schemes for different organ involvement of cSLE, and puts forward the treatment strategy of combination of traditional treatment and biological drugs, so as to better target the pathogenesis of cSLE, fully treat and control disease activity as soon as possible, reduce disease recurrence and side effects of traditional drugs, and provide reference for the continuous improvement of diagnosis and treatment of cSLE.

Key words: systemic lupus erythematosus, monogenic, biological drug, treat-to-target, child