Abstract:

Objective To summarize the clinical process of patients with non-Hodgkin 's lymphoma (NHL) secondary to acute leukemia after treatment, and to explore the mechanism of NHL secondary to acute leukemia after treatment. Methods The clinical data of child with T-lymphoblastic lymphoma (T-LBL) secondary to acute promyelocytic leukemia (APL) was retrospectively analyzed, and the literature reports of NHL secondary to acute leukemia after treatment were summarized. Results The patient was a 10-year-old boy who presented with "intermittent fever" and was diagnosed with APL. After treatment, bone marrow relapsed and a complete remission was achieved after adjusting the treatment regimen, however, T-LBL was diagnosed due to enlarged lymph nodes at the end of the leukemia treatment, and remission was achieved again after standardized chemotherapy. Searching the literature over the last 10 years, a total of 9 cases of non-Hodgkin's lymphoma secondary to acute leukemia treatment have been reported, all in adults, and 6 of these patients were disease-free survival up to the time of reporting. Conclusion The incidence of secondary NHL after acute leukemia treatment is low and the prognosis is favorable. In addition, for patients after chemotherapy for neoplastic diseases, it is crucial to monitor the incidence of secondary tumors and employ advanced diagnostic techniques to enhance understanding of the pathophysiology underlying these secondary malignancies.

Key words: acute promyelocytic leukemia, T-lymphoblastic lymphoma, child