Abstract:

Pediatric short bowel syndrome (SBS) is defined as a clinical condition characterized by impaired intestinal absorptive capacity resulting from extensive small bowel resection, bypass, or congenital short bowel, which fails to meet the nutritional requirements for normal growth and development, necessitating parenteral nutrition (PN) support for a duration exceeding 42 days. Owing to significant structural and functional abnormalities of the small intestine, pediatric SBS patients exhibit intestinal microecological dysbiosis, as evidenced by reduced microbial diversity and aberrant metabolic pathways. Key factors influencing the intestinal microbiota profiles in these patients include nutritional support modalities, prophylactic antibiotic administration, anatomical configuration, and growth and developmental status. Maintenance of intestinal microbiota diversity and stability is of paramount importance for enhancing intestinal barrier function, facilitating intestinal adaptation, and mitigating complications in pediatric SBS patients.

Key words: short bowel syndrome, intestinal microbiome, parenteral nutrition, child