锌在儿童炎症性肠病发生发展及治疗中的研究进展

doi:10.12372/jcp.2026.25e0166

摘要/Abstract

摘要：

炎症性肠病（IBD）是一种累及全消化道的慢性复发性炎症性疾病，营养素缺乏是IBD患者普遍存在的问题，锌作为人体维持细胞生理功能的重要营养素，在治疗诸多胃肠道疾病方面的益处得到广泛认可。近年来锌与IBD的相关机制研究不断涌现，越来越多的研究揭示了儿童IBD患者普遍存在锌缺乏的情况，缺锌与IBD患儿疾病复发，以及营养不良、生长发育迟缓、贫血等并发症发生有关。本文将回顾IBD与锌相关的基础及临床研究进展，为IBD的机制研究及优化治疗提供参考。

关键词: 锌, 炎症性肠病, 发病机制, 治疗, 儿童

Abstract:

Inflammatory bowel disease (IBD) is a chronic, recurrent inflammatory disease involving the entire gastrointestinal tract. Nutrient deficiencies are common in IBD patients, and zinc, as an important nutrient for the body to maintain the physiological cellular functions, is widely recognized as beneficial in the treatment of many gastrointestinal diseases. In recent years, research on the mechanism of zinc and IBD has been emerging continuously. More and more studies have revealed that zinc deficiency is common among children with IBD. Zinc deficiency is associated with disease recurrence in children with IBD, as well as the occurrence of complications such as malnutrition, growth retardation, and anemia. This article will review the progress of basic and clinical researches related to zinc and IBD, providing references for the mechanism research and optimized treatment of IBD.

Key words: zinc, inflammatory bowel disease, pathogenesis, therapy, child

中图分类号:

周圆可, 孙丽娜, 方莹. 锌在儿童炎症性肠病发生发展及治疗中的研究进展[J]. 临床儿科杂志, 2026, 44(1): 64-70.

ZHOU Yuanke, SUN Lina, FANG Ying. Research progress on the role of zinc in the occurrence, development and treatment of inflammatory bowel disease in children[J]. Journal of Clinical Pediatrics, 2026, 44(1): 64-70.

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