儿童髓母细胞瘤复发特征及治疗的研究进展

doi:10.12372/jcp.2023.22e1112

Abstract

Abstract:

Medulloblastoma (MB) is a common intracranial malignancy in children with a high recurrence rate despite standardized multimodal initial treatment. The prognosis of recurrent children is very poor even after intensive treatment. In recent years, the in-depth understanding of the clinical and biological characteristics of MB recurrence can guide the clinical design of relevant treatment strategies and implement of clinical trials. This paper reviews the research progress of the above contents, hoping to promote the speed of its clinical transformation and application, and finally benefit the clinical practice.

Key words: medulloblastoma, recurrent, therapy, child

ZHANG Zaiyu, WU Yuxin, LIANG Ping. Research progress on characterization and therapeutics for recurrent medulloblastoma in children[J].Journal of Clinical Pediatrics, 2023, 41(10): 708-714.

Figures/Tables 1

References 60

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临床试验名称	年龄	放射治疗方案	化学治疗方案	复发率/%	复发中位时间/a
HIT-SKK’2000^[12]	<4岁	化疗后完全缓解则不接受放疗	CTX+VCR+MTX+CBP+VP-16+ i.vc.MTX	37.5	1.3
Head Start I-II^[11]	<3岁	不接受放疗	诱导：CTX+VCR+VP-16+CDDP 巩固：CBP+VP-16+Thiotepa	33.3	NA
HIT-SIOP-PNET4^[10]	4~21岁	标准方案：全脑脊髓23.4 Gy+后颅窝54 Gy 超分割方案：全脑脊髓36 Gy+后颅窝60 Gy+瘤床68 Gy	CDDP+CCNU+VCR	19.5	2.2
SJMB96^[9]	3~21岁	标危组：全脑脊髓23.4 Gy+后颅窝36 Gy+瘤床55.8 Gy 高危组：全脑脊髓36~39.6 Gy+瘤床55.8 Gy+转移病灶50.4 Gy	VCR+CTX+CDDP	标危组/高危组： 15.1/29.2¹⁾	标危组/高危组： 2.0/1.6²⁾
SJMB03^[25]	3~21岁	标危组：全脑脊髓23.4 Gy+瘤床55.8 Gy 高危组：全脑脊髓36~39.6 Gy+瘤床55.8~59.4 Gy	VCR+CTX+CDDP	标危组/高危组： 16.3/34.0¹⁾	标危组/高危组： 2.0/1.3²⁾
SJYC07^[14]	<3岁	不接受放疗	诱导：MTX+VCR+CTX+CDDP 巩固：CTX+CBP+VP-16 维持：CTX+Topotecan+Erlotinib	65.8³⁾	0.7
COG-P9934^[13]	8月龄~3岁	化疗后完全缓解则不接受放疗	诱导：CTX+VCR+VP-16+CDDP 巩固：CBP+Thiotepa	39.2³⁾	NA

Research progress on characterization and therapeutics for recurrent medulloblastoma in children

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