新生儿高氨血症的早期诊断及精准干预

doi:10.12372/jcp.2023.23e0164

Abstract

Abstract:

Neonatal hyperammonemia (NHA) is a neonatal critical disease with high neonatal mortality and rapid progression. During the neonatal period, increased blood ammonia can be caused by a variety of genetic and non-genetic disorders with complex causes, such as urea cycle disorders, organic acidemia, fatty acid metabolism disorders, and acquired hyperammonemia due to other serious systemic diseases. The presenting clinical features are not specific. Early detection and identification of etiology and precise intervention through feeding management, amino-reducing drug and hemodialysis can improve the prognosis.

Key words: hyperammonemia, urea cycle disorder, inherited metabolic disorder, encephalopathy, neonate

ZHANG Yongjun, ZHU Tianwen. Early diagnosis and precise intervention of neonatal hyperammonemia[J].Journal of Clinical Pediatrics, 2023, 41(4): 241-246.

References 36

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Early diagnosis and precise intervention of neonatal hyperammonemia

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