儿童食管腐蚀伤的临床诊治研究进展

doi:10.12372/jcp.2025.24e0700

Abstract

Abstract:

Due to the age characteristics of children, esophageal damage caused by accidental ingestion of corrosive substances has become a common accidental injury for children. The acute injury and long-term sequelae resulting from esophageal corrosive injury have become the key and difficult points in the treatment of esophageal corrosive injury in children. This paper reviews the occurrence mechanism and the latest treatment schemes of esophageal corrosive injury, emphasizing the significance of correctly choosing emergency treatment measures and treatment plans for long-term sequelae, with the aim of reducing the occurrence of complications. It has practical guiding significance for the diagnosis and treatment of esophageal corrosive injury in children.

Key words: child, esophageal corrosion injury, accidental injury

LI Zhaofei, WANG Lingchao, ZHAO Dean. Research progress in clinical diagnosis and treatment of pediatric esophageal corrosive injury[J].Journal of Clinical Pediatrics, 2025, 43(3): 237-242.

References 27

[1]	Hall AH, Jacquemin D, Henny D, et al. Corrosive substances ingestion: a review[J]. Crit Rev Toxicol, 2019, 49(8): 637-669. doi: 10.1080/10408444.2019.1707773 pmid: 32009535
[2]	Gummin DD, Mowry JB, Beuhler MC, et al. 2019 annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 37th annual report[J]. Clin Toxicol (Phila), 2020, 58(12): 1360-1541.
[3]	Speidel AJ, Wölfle L, Mayer B, et al. Increase in foreign body and harmful substance ingestion and associated complications in children: a retrospective study of 1199 cases from 2005 to 2017[J]. BMC Pediatr, 2020, 20(1): 560.
[4]	Chen CC, Chen AC, Wu SF. Alkaline substances gastroesophageal injury in young children: emphasis on Asian food preparation habits[J]. J Formos Med Assoc, 2021, 120(10): 1907-1913.
[5]	Walsh K, Hughes I, Dheansa B. Management of chemical burns[J]. Br J Hosp Med (Lond), 2022, 83(3): 1-12. doi: 10.12968/hmed.2020.0056 pmid: 35377199
[6]	Zargar SA, Kochhar R, Mehta S, et al. The role of fiberoptic endoscopy in the management of corrosive ingestion and modified endoscopic classification of burns[J]. Gastrointest Endosc, 1991, 37(2): 165-169. doi: 10.1016/s0016-5107(91)70678-0 pmid: 2032601
[7]	Sarma MS, Tripathi PR, Arora S. Corrosive upper gastrointestinal strictures in children: difficulties and dilemmas[J]. World J Clin Pediatr, 2021, 10(6): 124-136. doi: 10.5409/wjcp.v10.i6.124 pmid: 34868889
[8]	Gregori D, Salerni L, Scarinzi C, et al. Foreign bodies in the upper airways causing complications and requiring hospitalization in children aged 0-14 years: results from the ESFBI study[J]. Eur Arch Otorhinolaryngol, 2008, 265(8): 971-978.
[9]	Jatana KR, Rhoades K, Milkovich S, et al. Basic mechanism of button battery ingestion injuries and novel mitigation strategies after diagnosis and removal[J]. Laryngoscope, 2017, 127(6): 1276-1282.
[10]	Khalaf RT, Ruan W, Orkin S, et al. Gastric injury secondary to button battery ingestions: a retrospective multicenter review[J]. Gastrointest Endosc, 2020, 92(2): 276-283. doi: S0016-5107(20)34191-2 pmid: 32334020
[11]	Xu G, Jia D, Chen J, et al. Esophageal button battery impactions in children: an analysis of 89 cases[J]. BMC Pediatr, 2024, 24(1): 388.
[12]	Hoffman RS, Burns MM, Gosselin S. Ingestion of caustic substances[J]. N Engl J Med, 2020, 382(18): 1739-1748.
[13]	Gaudreault P, Parent M, Mcguigan MA, et al. Predictability of esophageal injury from signs and symptoms: a study of caustic ingestion in 378 children[J]. Pediatrics, 1983, 71(5): 767-770. pmid: 6835760
[14]	Anderson KD, Rouse TM, Randolph JG. A controlled trial of corticosteroids in children with corrosive injury of the esophagus[J]. N Engl J Med, 1990, 323(10): 637-640.
[15]	徐果, 李兰, 冼志雄, 等. 儿童纽扣电池食管异物临床分析[J]. 中国耳鼻咽喉颅底外科杂志, 2022, 28(2): 103-106.
	Xu G, Li L, Xian ZX, et al. Clinical analysis of esophageal button battery ingestion in children[J]. Zhongguo Erbihou Ludi Waike Zazhi, 2022, 28(2): 103-106.
[16]	张海港, 樊明月, 赵兴贺. 15例儿童食管纽扣电池诊治经验[J]. 中华耳鼻咽喉头颈外科杂志, 2020, 55(1): 60-62.
	Zhang HG, Fan MY, Zhao XH. Experience of diagnosis and treatment of 15 cases of esophageal button battery in children[J]. Zhonghua Erbihou Toujing Waike Zazhi, 2020, 55(1): 60-62.
[17]	Soto PH, Reid NE, Litovitz TL. Time to perforation for button batteries lodged in the esophagus[J]. Am J Emerg Med, 2019, 37(5): 805-809. doi: S0735-6757(18)30594-1 pmid: 30054113
[18]	张丰珍, 段清川, 王桂香, 等. 儿童纽扣电池食管异物诊治研究进展[J]. 中华耳鼻咽喉头颈外科杂志, 2023, 58(4): 394-398.
	Zhang FZ, Duan QC, Wang GX, et al. Research progress of button battery ingestion in children[J]. Zhonghua Erbihou Toujing Waike Zazhi, 2023, 58(4): 394-398.
[19]	Wong J, Kovacic K, Lerner D. Esophageal Inflammatory Fibroid Polyp After Button Battery Ingestion[J]. J Pediatr Gastroenterol Nutr, 2021, 73(6): e126.
[20]	谷一超, 黄金狮, 廖俊敏, 等. 儿童食管腐蚀伤并发症的诊治分析[J]. 临床小儿外科杂志, 2023, 22(6): 554-557.
	Gu YC, Huang JS, Liao JM, et al. Analysis of diagnosing and treating complications related to esophageal corrosion in children[J]. Linchuang Xiaoer Waike Zazhi, 2023, 22(6): 554-557.
[21]	Voronetsky AN, Gulenko AV. Histological evaluation of esophageal stricture in children with caustic burn[J]. Khirurgiia (Mosk), 2023, 12): 43-51. doi: 10.17116/hirurgia202312143 pmid: 38088840
[22]	Bawazir O, Almaimani MO. Complications of esophageal strictures dilatation in children. A tertiary-center experience[J]. Saudi Med J, 2020, 41(7): 720-725. doi: 10.15537/smj.2020.7.25166 pmid: 32601640
[23]	El-Asmar KM, Youssef AA, Abdel-Latif M. The Effectiveness of combined balloon and bougie dilatation technique in children with impassable esophageal stricture[J]. J Laparoendosc Adv Surg Tech A, 2021, 31(6): 724-728. doi: 10.1089/lap.2020.0926 pmid: 33650883
[24]	Ahmadi M, Manzari-Tavakoli M, Javaherizadeh H, et al. Efficacy of endoscopic balloon dilation in Iranian pediatric patients with esophageal stricture[J]. Arq Gastroenterol, 2021, 58(4): 520-524. doi: 10.1590/S0004-2803.202100000-93 pmid: 34909860
[25]	Raboei E, Alabdali A, Sayed MH, et al. The outcome of pediatric esophageal strictures managed with endoscopic balloon dilation in Saudi Arabia[J]. J Laparoendosc Adv Surg Tech A, 2021, 31(2): 210-215. doi: 10.1089/lap.2020.0455 pmid: 33216676
[26]	唐鲁静, 楼金玕, 赵泓, 等. 内镜下食管扩张治疗儿童腐蚀性食管狭窄的临床分析[J]. 中国当代儿科杂志, 2023, 25(12): 1265-1269.
	Tang LJ, Lou JA, Zhao H, et al. Clinical analysis of endoscopic esophageal dilation for the treatment of corrosive esophageal strictures in children[J]. Zhongguo Dangdai Erke Zazhi, 2023, 25(12): 1265-1269.
[27]	El-Asmar KM, Allam AM. Predictors of successful endoscopic management of caustic esophageal strictures in children: When to stop the dilatations?[J]. J Pediatr Surg, 2021, 56(9): 1596-1599. doi: 10.1016/j.jpedsurg.2020.08.017 pmid: 32943196

Research progress in clinical diagnosis and treatment of pediatric esophageal corrosive injury

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