Abstract:

In recent years, antineoplastic therapy have been continuously improved, and the long-term survival rate of children and adolescents with tumor has been significantly increased. Therefore, the long-term quality of life has been paid more and more attention, especially for female children and adolescents. Due to fertility requirements, endocrine and reproductive problems have attracted much attention. Antineoplastic therapy may lead to ovarian insufficiency, affecting pubertal development and reproductive function. There is currently a lack of research that systematically describes the mechanisms by which antineoplastic therapy affects the ovarian function of pediatric patients. Based on the existing literature, this study summarizes the effects and mechanisms of antineoplastic therapy on ovarian function in children and adolescents, concludes the measures to reserve ovarian function, and discusses the limitations and future breakthroughs in this field. It is expected to promote the improvement of antineoplastic therapy strategies, retain children and adolescents’ reproductive function, and enhance their quality of life.

Key words: antineoplastic therapy, ovarian function, mechanism, protective measure, child, adolescents